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FENS Satellite Symposium Paris 8th July 2022

The crucial balance of NO signalling  from Synapse to Disease

FENS 2022


CNRS, UMR_7210
Sorbonne University
Institut de la Vision
17, rue Moreau
75012 Paris

Haitham Amal (Lab link)

Joern Steinert (Lab link)

The Symposium, lunch and coffee breaks are free. However, registration is mandatory. Residents and basic science students (undergraduate and doctoral) and researchers (at all levels) are encouraged to participate.
Registration: Please complete this registration form
Registration deadline: 7 JULY 2022


This Satellite Symposium brings together researchers from world-leading laboratories studying the elusive roles of NO signalling in the brain. We will focus on physiological and pathological effects of this so-called Janus molecule which is involved in regulating proliferation, survival and differentiation of neurons, in synaptic activity, neural plasticity and memory function. NO is a crucial molecule to promote survival and differentiation of neural cells and exerts long-lasting effects through regulation of transcription factors and modulation of gene expression. 

Over recent years, research studying nitrergic signalling to characterise its role in physiology and disease has progressed substantially and this symposium is timely as it will discuss those recent findings which have not been presented in recent meetings. The invited speakers with diverse backgrounds will focus on the functions of NO and relevant signalling molecules in neurophysiology and pathology.

List of Speakers

  • Prof. João Laranjinha

  • Prof. Alan Jasanoff

  • Dr. Konstantina Chachlaki

  • Prof. Stuart Lipton

  • Dr. Giuditta Gambino

  • Dr. Haitham Amal

  • Dr. Daniela Puzzo

  • Dr. Ana Ledo

  • Dr. Joern Steinert

  • Prof. Doris Koesling 

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Pipetting Samples

Signalling from Synapse to Disease


Nitric Oxide volume diffusion reaches pre- and post-synaptic targets

Neurons are stained for tyrosine hydroxylase and redox stress (4-HNE)

Mass Spectrometry allows detection of modified proteins

fMRI imaging assesses morphological and functional changes in the brain  

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8th July 2022


Welcome and introduction to the symposium.

Introduction to the Symposium, house keeping and Acknowledgement of Sponsors


Presentation by Scientifica - Sponsor of the Symposium


Prof. João Laranjinha (University of Coimbra)

Regulation of neurovascular coupling by nitric oxide during aging and neurodegenerative conditions: the role of dietary nitrate on cognitive enhancement


Prof. Alan Jasanoff (MIT)

Detection and manipulation of nitric oxide in molecular-level MRI


Dr. Konstantina Chachlaki (University of Lille

Associative mechanisms linking a defective minipuberty to the appearance of mental and non-mental disorders: infantile NO replenishment as a new therapeutic possibility

10.50 - 11.50

Coffee Break


Dr Giuditta Gambino (University of Palermo)

Nitrergic signalling and TRPV1 channels as putative targets of cannabinoid-mediated neuroprotection: impact on neuronal hyperexcitability and epilepsy?


Dr.  Haitham Amal (The Hebrew University of Jerusalem)

Nitric Oxide: from systems biology to drug targets in autism spectrum disorders

12.50 - 14.15

Lunch and coffee provided in the cafeteria


Presentation by CoolLED - Sponsor of the Symposium


Dr. Joern Steinert (University of Nottingham)

Neuroinflammatory signalling as potential treatment target in neurodegenerative conditions


Dr. Daniela Puzzo (University of Catania)

Role of the NO/cGMP pathway in learning and memory: from physiology to Alzheimer’s disease

15.20 - 16.00

Coffee Break


Dr. Ana Ledo (University Coimbra)

Changing bioactivity of nitric oxide in brain aging and neurodegeneration: implications on brain energy metabolism


Prof. Doris Koesling (University Bochum)

NO/cGMP signalling within synaptic transmission


Prof. Stuart Lipton (The Scripps Research Institute and UC San Diego)

Hidden Networks of Transnitrosylated Proteins Underlie the Synaptic Loss Causing Cognitive Deficits in Neurodegenerative Diseases


Discussion and Concluding remarks


Symposium Dinner for speakers


Names and affiliations of speakers:


Prof. João Laranjinha - Professor of Biochemistry and Molecular Biology Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga, 3004-504, Coimbra, Portugal


Prof. Stuart Lipton - Professor and Founding Director, Neurodegeneration New Medicines Center, Step Family Foundation Endowed Chair, Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California; Professor of Neurosciences/Neurology, University of California San Diego School of Medicine and Yale School of Medicine


Prof. Alan Jasanoff - Professor of Biological Engineering, Brain & Cognitive Sciences, Nuclear Science & Engineering, MIT, USA

Prof. Daniela Puzzo - Associate Professor of Physiology, Department Biomedical and Biotechnological Sciences, University of Catania, Catania 95123, Italy


Dr. Ana Ledo - Professora Auxiliar, Universidade de Coimbra Faculdade de Farmácia Azinhaga de Santa Comba 3000-548 Coimbra  Portugal 


Dr. Joern Steinert - Assistant Professor in Neuroscience, School of Life Sciences, Queen Medical Centre, University Nottingham, UK


Dr. Haitham Amal - Assistant Professor, Faculty of Medicine, The Institute for Drug Research (IDR) The School of Pharmacy, The Hebrew University of Jerusalem, Israel


Dr. Giuditta Gambino - Lecturer in Human Physiology, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), Section of Human Physiology, University of Palermo. 90134, Palermo, Italy

Dr. Konstantina Chachlaki - Scientific coordinator of miniNO, Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, UMR-S 1172, F-59000, Lille, France

Prof. Doris Koesling - Professor for Biology, Ruhr-Universität Bochum, Medizinische Fakultät MA N1 - 44780 Bochum, Germany

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